Pandey, K and Sharma, SK (2020) Activity- and memory training-induced acetylation of α-tubulin in the hippocampus. Neurobiol Learn Mem, 171 (107226).

Text 1-s2.0-S1074742720300708-main.pdf Restricted to Repository staff only Download (818Kb) | Request a copy

Abstract

Posttranslational modifications play crucial roles in synaptic plasticity and memory formation. The important role of histone acetylation is well established in these processes. However, activity-dependent regulation of acetylation of non-histone proteins is not well understood. We previously showed that α-tubulin is acetylated in an activity-dependent manner. Here, we show that cyclin-dependent kinase 5 (CDK5) plays an important role in α-tubulin acetylation induced by KCl depolarization or N-methyl-D-aspartate stimulation of the hippocampal slices. In addition, KCl depolarization inhibits the activity of SIRT2, an α-tubulin deacetylase. The inhibitory effect of KCl on SIRT2 activity requires CDK5 activity. Furthermore, α-tubulin acetylation is enhanced by memory training in object recognition task. These results suggest that memory formation may involve α-tubulin acetylation

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	20 Apr 2020 05:28
Last Modified:	08 Jul 2021 07:45
URI:	http://nbrc.sciencecentral.in/id/eprint/688

Actions (login required)

View Item