Mandal, Pravat K and Shukla, Deepika and Govind, Varan and Boulard, Yves and Ersland, Lars (2017) Glutathione Conformations and Its Implications for in Vivo Magnetic Resonance Spectroscopy. J Alzheimers Dis, 59 (2). pp. 537-541.

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Abstract

Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	18 Feb 2020 09:30
Last Modified:	13 Dec 2021 09:57
URI:	http://nbrc.sciencecentral.in/id/eprint/673

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