Mandal, S and Debnath, K and Jana, NR and Jana, Nikhil R (2017) Trehalose-Functionalized Gold Nanoparticle for Inhibiting Intracellular Protein Aggregation. Langmuir, 33 (49). pp. 13996-14003.

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Abstract

rehalose is a well-known antiamyloidogenic molecule that inhibits protein aggregation under the intracellular/extracellular condition, and recent work shows that the nanoparticle form of trehalose can further enhance this performance. Here we have designed a trehalose-functionalized Au nanoparticle that can inhibit the aggregation of a polyglutamine-containing mutant protein inside the neuronal cell. Designed nanoparticles have a 20-30 nm Au core with about 350 ± 50 trehalose molecules per particle on the surface on average. They enter the cell, inhibit mutant protein aggregation, and enhance the cell survival against toxic protein aggregates. This work extends the application potential of trehalose for the understanding and treatment of different diseases involving protein aggregation.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	18 Feb 2020 08:59
Last Modified:	18 Feb 2020 08:59
URI:	http://nbrc.sciencecentral.in/id/eprint/671

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