Pai, Praful P and Mandal, Pravat K and Punjabi, Khushboo and Shukla, Deepika and Goel, Aanshika and Joon, Shallu and Roy, Saurav and Sandal, Kanika and Mishra, Ritwick and Lahoti, Ritu (2020) BRAHMA: Population specific T1, T2, and FLAIR weighted brain templates and their impact in structural and functional imaging studies. Magn Reson Imaging, 70. pp. 5-21.

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Abstract

Differences in brain morphology across population groups necessitate creation of population-specific Magnetic Resonance Imaging (MRI) brain templates for interpretation of neuroimaging data. Variations in the neuroanatomy in a genetically heterogeneous population make the development of a population-specific brain template for the Indian subcontinent imperative. A dataset of high-resolution 3D T1, T2, and FLAIR images acquired from a group of 113 volunteers (M/F - 56/57, mean age 28.96 ± 7.80 years) are used to construct T1, T2, and FLAIR templates, collectively referred to as Indian Brain Template, "BRAHMA". A processing pipeline is developed and implemented in a MATLAB based toolbox for template construction and generation of tissue probability maps and segmentation atlases, with additional labels for deep brain regions such as the Substantia Nigra generated from the T2 and FLAIR templates. The use of BRAHMA template for analysis of structural and functional neuroimaging data from Indian participants provides improved accuracy with statistically significant results over that obtained using the ICBM-152 (International Consortium for Brain Mapping) template. Our results indicate that segmentations generated on structural images are closer in volume to those obtained from registration to the BRAHMA template than to the ICBM-152. Furthermore, functional MRI data obtained for Working Memory and Finger Tapping paradigms processed using the BRAHMA template shows a significantly higher percentage of the activation area than ICBM-152 in relevant brain regions, i.e. the left middle frontal gyrus, and the left and right precentral gyri, respectively. The availability of different image contrasts, tissue maps, and segmentation atlases makes the BRAHMA template a comprehensive tool for multi-modal image analysis in laboratory and clinical settings.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	04 Feb 2020 11:50
Last Modified:	13 Dec 2021 09:42
URI:	http://nbrc.sciencecentral.in/id/eprint/540

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