Kumar, Ashutosh and Kumar, Pavan and Pareek, Vikas and Faiq, Muneeb A and Narayan, Ravi K and Raza, Khursheed and Prasoon, Pranav and Sharma, Vivek K (2019) Neurotrophin Mediated Hpa Axis Dysregulation in Stress Induced Genesis of Psychiatric Disorders: Orchestration by Epigenetic Modifications. J Chem Neuroanat, 102. p. 101688.

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Abstract

Apart from their established role in embryonic development, neurotrophins (NTs) have diverse functions in thenervous system. Their role in the integration of physiological and biochemical aspects of the nervous system iscurrently attracting much attention. Based on a systematic analysis of the literature, we here propose a newparadigm that, by exploiting a novel role of NTs, may help explain the genesis of stress-related psychiatricdisorders, opening new avenues for better management of the same. We hypothesize that NTs as an integratednetwork play a crucial role in maintaining an indivdual’s psychological wellbeing. Given the evidence that stresscan induce chronic disruption of the hypothalamic-pituitary-adrenal (HPA) axis which, in turn, is causally linkedto several psychiatric disorders, this function may be mediated through the homeostatic mechanisms governingregulation of this axis. In fact, NTs, such as nerve growth factor (NGF) and brain derived neurotrophic factor(BDNF) are known to participate in neuroendocrine regulation. Recent studies suggest epigenetic modification ofNT-HPA axis interplay in the precipitation of psychiatric disorders. Our article highlights why this newknowledge regarding NTs should be considered in the etiogenesis and treatment of stress-induced psycho-pathology

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	17 Oct 2019 05:05
Last Modified:	14 Dec 2021 05:15
URI:	http://nbrc.sciencecentral.in/id/eprint/523

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