![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Godavarthi, SK and Narender, D and Mishra, A and Goswami, A and Rao, SN and Nukina, N and Jana, NR (2009) Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction. Journal of Neurochemistry, 108 (3). pp. 787-795.
|
Text
Induction of chemokines, MCP-1, and KC.pdf Download (458Kb) | Preview |
Abstract
Huntington's disease is a hereditary neurodegenerative disorder caused by an aberrant polyglutamine expansion in the amino terminus of the huntingtin protein. The resultant mutant huntingtin form aggregates in neurons and causes neuronal dysfunction and degeneration in many ways including transcriptional dysregulation. Here, we report that the expression of mutant huntingtin in the mouse neuroblastoma cell results in massive transcriptional induction of several chemokines including monocyte chemoattractant protein-1 (MCP-1) and murine chemokine (KC). The mutant huntingtin expressing cells also exhibit proteasomal dysfunction and down-regulation of NF-kappaB activity in a time-dependent manner and both these phenomena regulate the expression of MCP-1 and KC. The expression of MCP-1 and KC are increased in the mutant huntingtin expressing cells in response to mild proteasome inhibition. However, the expression of MCP-1 and KC and proteasome activity are not altered and inflammation is rarely observed in the brain of 12-week-old Huntington's disease transgenic mice in comparison with their age-matched controls. Our result suggests that the mutant huntingtin-induced proteasomal dysfunction can up-regulate the expression of MCP-1 and KC in the neuronal cells and therefore might trigger the inflammation process
| Item Type: | Article |
|---|---|
| Subjects: | Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology |
| Depositing User: | Dr. D.D. Lal |
| Date Deposited: | 16 May 2018 04:25 |
| Last Modified: | 17 Mar 2020 04:04 |
| URI: | http://nbrc.sciencecentral.in/id/eprint/384 |
Actions (login required)
 |
View Item |