Mukherjee, Sriparna and Ghosh, Sourish and Nazmi, Arshed and Basu, Anirban (2015) RIG-I Knockdown Impedes Neurogenesis in a Murine Model of Japanese Encephalitis. Cell Biology International, 39 (2). pp. 224-229.

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Abstract

Retinoic acid inducible gene I (RIG-I) is a well established pattern recognition receptor (PRR) in neurons infected with Japanese encephalitis virus (JEV) as reported previously from our laboratory. Japanese encephalitis (JE) virus infection in brain has been shown to decrease the proliferation of neural stem/progenitor cells (NSPCs) which has its implications in neurological sequelae in JE survivors. We have found that ablation of RIG-I both in vivo and in vitro models results in significant decrease in NSPC proliferation post JEV infection. We hypothesize that knockdown of RIG-I diminishes the expression of antiviral molecules resulting in an increase in viral replication, which in turn results in enhancement of the expression of cell cycle inhibitors, hence affecting the proliferation of NSPCs.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	13 Jul 2017 07:06
Last Modified:	09 Dec 2021 11:35
URI:	http://nbrc.sciencecentral.in/id/eprint/229

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