Pandey, K and Sharma, KP and Sharma, SK (2015) Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory. Learn Mem, 22 (10). pp. 514-518.

Text 85_Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.pdf Restricted to Registered users only Download (423Kb) | Request a copy

Abstract

Massed training is less effective for long-term memory formation than the spaced training. The role of acetylation in synaptic plasticity and memory is now well established. However, the role of this important protein modification in synaptic plasticity induced by massed pattern of stimulation or memory induced by massed training is not well understood. Here we show that increasing the level of acetylation enhances long-term potentiation induced by massed pattern of high frequency stimulation. Furthermore, enhancing acetylation level facilitates long-term memory by massed training. Thus, increasing acetylation level facilitates synaptic plasticity and memory by massed patterns.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	13 Jul 2017 05:01
Last Modified:	09 Jan 2018 07:03
URI:	http://nbrc.sciencecentral.in/id/eprint/212

Actions (login required)

View Item