Haldipur, P and Sivaprakasam, I and Periasamy, V and Govindan, S and Mani, S (2015) Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum. Biol Open, 4 (7). pp. 865-872.

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Abstract

The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	12 Jul 2017 06:09
Last Modified:	13 Mar 2020 05:26
URI:	http://nbrc.sciencecentral.in/id/eprint/201

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