[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Mukherjee, S and Ghosh, S and Nazmi, A and Basu, A (2015) RIG-I Knockdown Impedes Neurogenesis in a Murine Model of Japanese Encephalitis. Cell Biology International, 39 (2). pp. 224-229.

[img] Text
67_RIG-I Knockdown Impedes Neurogenesis in a Murine Model of Japanese Encephalitis.pdf
Restricted to Registered users only

Download (639Kb)

Abstract

Retinoic acid inducible gene I (RIG-I) is a well established pattern recognition receptor (PRR) in neurons infected with Japanese encephalitis virus (JEV) as reported previously from our laboratory. Japanese encephalitis (JE) virus infection in brain has been shown to decrease the proliferation of neural stem/progenitor cells (NSPCs) which has its implications in neurological sequelae in JE survivors. We have found that ablation of RIG-I both in vivo and in vitro models results in significant decrease in NSPC proliferation post JEV infection. We hypothesize that knockdown of RIG-I diminishes the expression of antiviral molecules resulting in an increase in viral replication, which in turn results in enhancement of the expression of cell cycle inhibitors, hence affecting the proliferation of NSPCs.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Mr D.D. Lal
Date Deposited: 13 Jul 2017 07:06
Last Modified: 08 Aug 2017 04:46
URI: http://nbrc.sciencecentral.in/id/eprint/229

Actions (login required)

View Item View Item