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Haldipur, P and Sivaprakasam, I and Periasamy, V and Govindan, S and Mani, S (2015) Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum. Biol Open, 4 (7). pp. 865-872.

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Abstract

The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Mr D.D. Lal
Date Deposited: 12 Jul 2017 06:09
Last Modified: 08 Aug 2017 05:06
URI: http://nbrc.sciencecentral.in/id/eprint/201

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