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Number of items: 65.

Article

Joshi, T and Kumar, V and Kaznacheyeva, EV and Jana, NR (2021) Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington’s Disease. Mol Neurobiol, 58. pp. 3992-4006.

Kumar, V and Joshi, T and Vatsa, N and Singh, BK and Jana, NR (2019) Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse. Front Mol Neurosci, 12 (289).

Vatsa, N and Kumar, V and Singh, BK and Kumar, SS and Sharma, A and Jana, NR (2019) Down-Regulation of Mirna-708 Promotes Aberrant Calcium Signaling by Targeting Neuronatin in a Mouse Model of Angelman Syndrome. Frontiers in Molecular Neuroscience, 12 (35).

Matai, L and Sarkar, GC and Chamoli, M and Malik, Y and Kumar, SS and Rautela, U and Jana, NR and Chakraborty, K and Mukhopadhyay, A (2019) Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis. Proc Natl Acad Sci U S A,, 116 (35). pp. 17383-17392.

Pradhan, N and Debnath, K and Mandal, S and Jana, Nikhil R and Jana, NR (2018) Antiamyloidogenic Chemical/Biochemical-Based Designed Nanoparticle as Artificial Chaperone for Efficient Inhibition of Protein Aggregation. Biomacromolecules, 19 (6). pp. 1721-1731.

Rai, A and Singh, PK and Singh, V and Mishra, R and Thakur, AK and Mahadevan, A and Shankar, SK and Jana, NR and Ganesh, S (2018) Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux. Cell Death and Disease, 9 (2).

Singh, BK and Vatsa, N and Nelson, VK and Kumar, V and Kumar, SS and Mandal, SC and Pal, M and Jana, NR (2018) Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington’s Disease. Molecular Neurobiology, 55 (8). pp. 6337-6346.

Debnath, K and Jana, NR and Jana, Nikhil R (2018) Designed Polymer Micelle for Clearing Amyloid Protein Aggregates via Up-Regulated Autophagy. ACS Biomaterials Science & Engineering, 5 (1). pp. 390-401.

Vatsa, N and Jana, NR (2018) Ube3a and Its Link with Autism. Front Mol Neurosci, 11 (448).

Mandal, S and Debnath, K and Jana, NR and Jana, Nikhil R (2017) Trehalose-Functionalized Gold Nanoparticle for Inhibiting Intracellular Protein Aggregation. Langmuir, 33 (49). pp. 13996-14003.

Amanullah, A and Upadhyay, A and Joshi, V and Mishra, R and Jana, NR and Mishra, A (2017) Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration. Progress in Neurobiology, 159. pp. 1-38.

Shekhar, S and Vatsa, N and Kumar, V and Singh, BK and Jamal, I and Sharma, A and Jana, NR (2017) Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease. Human Molecular Genetics, 26 (2). pp. 420-429.

Jamal, I and Kumar, V and Vatsa, N and Singh, BK and Shekhar, S and Sharma, A and Jana, NR (2017) Environmental Enrichment Improves Behavioral Abnormalities in a Mouse Model of Angelman Syndrome. Molecular Neurobiology, 54 (7). pp. 5319-5326.

Jamal, I and Kumar, V and Vatsa, N and Shekhar, S and Singh, BK and Sharma, A and Jana, NR (2017) Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome. Neurobiology of Disease, 105. pp. 99-108.

Singh, BK and Vatsa, N and Kumar, V and Shekhar, S and Sharma, A and Jana, NR (2017) Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer's disease. Human Molecular Genetics, 26 (20). pp. 4042-4054.

Debnath, K and Pradhan, N and Singh, BK and Jana, NR and Jana, Nikhil R (2017) Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington's Disease Model Mouse. ACS, 9 (26). pp. 24126-24139.

Majumder, Piyali and Roy, K and Singh, BK and Jana, NR and Mukhopadhyay, Debashis (2017) Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario. y The Company of Biologists, 10 (5). pp. 655-669.

Kumar, R and Jangir, DK and Verma, G and Shekhar, S and Hanpude, P and Kumar, S and Kumari, R and Singh, N and Bhavesh, NS and Jana, NR and Maiti, TK (2017) S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation. Scientific Reports, 7 (44558).

Pradhan, N and Shekhar, S and Jana, NR and Jana, Nikhil R (2017) Sugar-Terminated Nanoparticle Chaperones Are 102-105 Times Better Than Molecular Sugars in Inhibiting Protein Aggregation and Reducing Amyloidogenic Cytotoxicity. ACS Appl Mater Interfaces, 9 (12). pp. 10554-10566.

Debnath, K and Shekhar, S and Kumar, V and Jana, NR (2016) Efficient Inhibition of Protein Aggregation, Disintegration of Aggregates, and Lowering of Cytotoxicity by Green Tea Polyphenol-Based Self-Assembled Polymer Nanoparticles. Applied Materials & Interface, 8 (31). pp. 20309-20318.

Godavarthi, SK and Dey, P and Sharma, A and Jana, NR (2015) Impaired adult hippocampal neurogenesis and its partial reversal by chronic treatment of fluoxetine in a mouse model of Angelman syndrome. Biochem Biophys Res Commu, 464 (4). pp. 1196-1201.

Chakraborty, M and Paul, BK and Nayak, T and Das, A and Jana, NR and Bhutani, S (2015) The E3 ligase ube3a is required for learning in Drosophila melanogaster. Biochem Biophys Res Commun, 462 (1). pp. 71-77.

Chakraborty, J and Rajamma, U and Jana, NR and Mohanakumar, KP (2015) Quercetin improves the activity of the ubiquitin-proteasomal system in 150Q mutated huntingtin-expressing cells but exerts detrimental effects on neuronal survivability. Journal of Neuroscience Research, 93 (10). pp. 1581-1591.

Maheshwari, M and Shekhar, S and Singh, BK and Jamal, I and Vatsa, N and Kimar, V and Sharma, A and Jana, NR (2014) Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology. Hum Mol Genet, 23 (23). pp. 6235-6245.

Godavarthi, SK and Sharma, A and Jana, NR (2014) Reversal of reduced parvalbumin neurons in hippocampus and amygdala of Angelman syndrome model mice by chronic treatment of fluoxetine. J Neurochem, 130 (4). pp. 444-454.

Palmal, S and Maity, AR and Singh, BK and Basu, S and Jana, NR (2014) Inhibition of amyloid fibril growth and dissolution of amyloid fibril by curcumin-gold nanoparticle. Chemistry-a European Journal, 20 (20). pp. 6184-6191.

Maheshwari, M and Bhutani, S and Das, A and Mukherjee, R and Sharma, A and Kino, Y and Nukina, N and Jana, NR (2014) Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease. Hum Mol Genet., 23 (10). pp. 2737-2751.

Palmal, S and Jana, NR and Jana, Nikhil R (2014) Inhibition of amyloid fibril growth by nanoparticle coated with histidine-based polymer. Journal of Physical Chemistry, 118. pp. 21630-21638.

Sharma, J and Mukherjee, D and Rao, S and Iyengar, S and Shankar, SK and Satishchandra, P and Jana, NR (2013) Neuronatin mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease. J Biol Chem, 288 (13). pp. 9482-9490.

Mishra, A and Maheshwari, M and Chhangani, D and Fujimori, N and Endo, F and Joshi, AP and Jana, NR and Yamanaka, K (2013) E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. Neurobiology of Aging, 1310. pp. 11-23.

Baksi, S and Jana, NR and Bhattacharyya, NP (2013) Grb2 Is Regulated by Foxd3 and Has Roles in Preventing Accumulation and Aggregation of Mutant Huntingtin. Plos One, 8 (10). e76792.

Das, E and Jana, NR and Bhattacharyya, NP (2013) MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells. Biochemical and Biophysical Research Communications. ResearchGate, 437. pp. 217-224.

Chhangani, D and Jana, NR and Mishra, A (2013) Misfolded Proteins Recognition Strategies of E3 Ubiquitin Ligases and Neurodegenerative Diseases. Molecular Neurobiology, 47. pp. 302-312.

Bhutani, S and Das, A and Maheshwari, M and Lakhotia, SC and Jana, NR (2012) Dysregulation of core components of SCF complex in poly-glutamine disorders. Cell Death Dis, 3. e428.

Maheshwari, M and Samanta, A and Godavarthi, SK and Mukherjee, R and Jana, NR (2012) Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease. J Biol Chem, 278 (35). pp. 29949-29957.

Godavarthi, SK and Dey, P and Maheshwari, M and Jana, NR (2012) Defective glucocorticoid hormone receptor signaling leads to increased stress and anxiety in a mouse model of Angelman syndrome. Hum Mol Genet., 21 (8). pp. 1824-1834.

Jana, NR (2012) Protein homeostasis and aging: role of ubiquitin protein ligases. Neurochem Int., 60 (5). pp. 443-447.

Maheshwari, M and Jana, NR (2012) Withdrawn: Potential Role of Ubiquitin Ligase Ube3a in Synaptic Pathophysiology of Huntington's Disease. Int J Dev Neurosci.

Sharma, J and Mulherkar, S and Mukherjee, D and Jana, NR (2012) Malin regulates Wnt signaling pathway through degradation of dishevelled2. J Biol Chem, 287 (9). pp. 6830-6839.

Jana, NR (2012) Understanding the Pathogenesis of Angelman Syndrome through Animal Models. Neural Plasticity, 2012.

Sharma, JP and Roa, SN and Shankar, SK and Satishchandra, P and Jana, NR (2011) Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis. Neurobiology of Disease, 44. pp. 133-141.

Ghose, J and Sinha, M and Das, E and Jana, NR and Bhattacharyya, NP (2011) Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease. PLoS One, 6 (8). e23837.

Rao, SN and Maity, R and Sharma, JP and Dey, P and Shankar, SK and Satishchandra, P and Jana, NR (2010) Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin. Human Molecular Genetics, 19 (23).

Maity, R and Sharma, J and Jana, NR (2010) Capsaicin Induces Apoptosis through Ubiquitin-Proteasome System Dysfunction. J Cell Biochem, 109 (5). pp. 933-942.

Rao, SN and Sharma, J and Maity, R and Jana, NR (2010) Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease. The Journal of Biological Chemistry, 285 (2). pp. 1404-1413.

Mulherkar, SA and Jana, NR (2010) Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome. Neurobiology of Disease, 40. pp. 586-592.

Godavarthi, SK and Narender, D and Mishra, A and Goswami, A and Rao, SN and Nukina, N and Jana, NR (2009) Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction. Journal of Neurochemistry, 108 (3). pp. 787-795.

Mishra, A and Godavarthi, SK and Jana, NR (2009) UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27. Neurobiology of Disease, 36 (1). pp. 26-34.

Mishra, A and Godavarthi, SK and Maheshwari, M and Goswami, A and Jana, NR (2009) The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins. Journal of Biological Chemistry, 284 (16). pp. 10735-10745.

Mulherkar, SA and Sharma, J and Jana, NR (2009) The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. JOURNAL OF NEUROCHEMISTRY, 110 (6). pp. 1955-1964.

Mishra, A and Dikshit, P and Purkayastha, S and Sharma, J and Nukina, N and Jana, NR (2008) E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 283 (12). pp. 7648-7656.

Jana, NR (2008) Nsaids and Apoptosis. Cell Mol Life Sci, 65 (9). pp. 1295-1301.

Mishra, A and Jana, NR (2008) Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome. Cell. Mol. Life Sci., 65 (4). pp. 656-666.

Dikshit, P and Jana, NR (2008) Role of Ubiquitin Protein Ligases in the Pathogenesis of Polyglutamine Diseases. Neurochem Res, 33 (5). pp. 945-951.

Dikshit, P and Jana, NR (2007) The co-chaperone CHIP is induced in various stresses and confers protection to cells. Biochemical and Biophysical Research Communications, 357 (3). pp. 761-765.

Dikshit, P and Goswami, A and Mishra, A and Nukina, N and Jana, NR (2006) Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction. Biochem Biophys Res Commun, 342 (4). pp. 1323-1328.

Goswami, A and Dikshit, P and Mishra, A and Mulherkar, S and Nukina, N and Jana, NR (2006) Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochem Biophys Res Commun, 342 (2). pp. 184-190.

Dikshit, P and Chatterjee, M and Goswami, A and Mishra, A and Jana, NR (2006) Aspirin induces apoptosis through the inhibition of proteasome function. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (39). pp. 29228-29235.

Goswami, A and Dikshit, P and Mishra, A and Nukina, N and Jana, NR (2006) Expression of expanded polyglutamine proteins suppresses the activation of transcription factor NFkappaB. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (48). pp. 37017-37024.

Jana, NR and Nukina, N (2005) BAG-1 associates with the polyglutamine-expanded huntingtin aggregates. Neurosci Lett, 378 (3). pp. 171-175.

Jana, NR and Dikshit, P and Goswami, A and Kotliarova, S and Murata, S and Tanaka, K and Nukina, N (2005) Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280 (12). pp. 11635-11640.

Jana, NR and Nukina, N (2004) Assessment of impaired proteasomal function in a cellular model of polyglutamine diseases. Methods Mol Biol, 277. pp. 287-292.

Jana, NR and Dikshit, P and Goswami, A and Nukina, N (2004) Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 279 (12). pp. 11680-11685.

Jana, NR and Nukina, N (2004) Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD. Neurotox Res, 6 (7-8). pp. 523-533.

Jana, NR and Nukina, N (2003) Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway. J Chem Neuroanat, 26 (2). pp. 95-101.

This list was generated on Tue Dec 7 04:54:31 2021 IST.