Chaudhuri, Rituparna and Arora, Himali and Seth, Pankaj (2021) Mitochondrial Calcium Signaling in the Brain and Its Modulation by Neurotropic Viruses. Mitochondrion, 59. pp. 8-16.

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Abstract

Calcium (Ca2+) plays fundamental and diverse roles in brain cells as a second messenger of many signaling pathways. Given the high energy demand in the brain and the generally non-regenerative state of neurons, the role of brain mitochondrial calcium [Ca2+]m in particular, in regulating ATP generation and determination of cell fate by initiation or inhibition of programmed cell death (PCD) becomes critical. Since [Ca2+]m signaling has a central role in brain physiology, it represents an ideal target for viruses to hijack the Ca2+ machinery to favor their own persistence, replication and/or dissemination by modulating cell death. This review discusses the ways by which neurotropic viruses are known to exploit the [Ca2+]m signaling of their host cells to regulate cell death in the brain, particularly in neurons. We hope our review will highlight the importance of [Ca2+]m handling in the virus-infected brain and stimulate further studies towards exploring novel [Ca2+]m related therapeutic strategies for viral effects on the brain.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	06 Aug 2021 05:59
Last Modified:	16 Dec 2021 07:35
URI:	http://nbrc.sciencecentral.in/id/eprint/761

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