Sathiyaseelan, A and Saravanakumar, K and Jayalakshmi, J and Gopi, M and Shajahan, A and Barathikannan, K and Kalaichelvan, PT and Wang, MH (2020) Trigonelline-Loaded Chitosan Nanoparticles Prompted Antitumor Activity on Glioma Cells and Biocompatibility with Pheochromocytoma Cells. Int J Biol Macromol, 163. pp. 36-43.

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Abstract

Trigonelline-loaded water-soluble chitosan nanoparticles (Trigo-WSCS NPs) were prepared for the treatment ofglioblastoma (targeting C6 glioma cells) and also evaluated its biocompatibility with rat adrenal pheochromocy-toma cells (PC12 cells). WSCS-Trigo NPs characteristics were determined using UV–Visible spectrophotometer,FTIR, XRD, TEM, DLS, and Zeta potential. Trigo-WSCS NPs were noted to have a spherical shape, with an averagesize of 356 nm. Trigo-WSCS NPs zeta potential was 30.9 mv, which expresses its good stability. The WSCS-TrigoNPs considerably inhibited the growth of rat C6 glioma cells and exhibited an IC50concentration of 34μg/mL. Fur-ther, Trigo-WSCS NPs were biocompatible with PC12 cells in terms of enhancing neurite growth and differenti-ation. In conclusion, Trigo-WSCS NPs could act as an antitumor drug for the treatment of glioblastoma assuggested by thein vitrostudies.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	03 Aug 2021 05:13
Last Modified:	03 Aug 2021 05:14
URI:	http://nbrc.sciencecentral.in/id/eprint/722

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