Yelamanchi, SD and Tyagi, A and Mohanty, V and Dutta, P and Korbonits, M and Chavan, S and Advani, J and Madugundu, AK and Dey, G and Datta, KK and Rajyalakshmi, M and Sahasrabuddhe, NA and Chaturvedi, A and Kumar, A and Das, AA and Ghosh, D and Jogdand, GM and Nair, HH and Saini, K and Panchal, M and Sarvaiya, MA and Mohanraj, SS and Sengupta, N and Saxena, P and Subramani, PA and Kumar, P and Akkali, R and Reshma, SV and Santhosh, RS and Rastogi, S and Kumar, S and Ghosh, SK and Irlapati, VK and Srinivasan, A and Radotra, BD and Mathur, PP and Wong, GW and Satishchandra, P and Chatterjee, A and Gowda, H and Bhansali, A and Pandey, A and Shankar, SK and Mahadevan, A and Prasad, TSK (2018) Proteomic Analysis of the Human Anterior Pituitary Gland. OMICS, 22 (12). pp. 759-769.

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Abstract

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	18 Feb 2020 12:12
Last Modified:	12 Mar 2020 06:09
URI:	http://nbrc.sciencecentral.in/id/eprint/677

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