Mukhopadhyay, Rupanjan and Mishra, Manoj Kumar and Basu, Anirban and Bishayi, Biswadev (2009) Modulation of Steroidogenic Enzymes in Murine Lymphoid Organs after Immunization with Soluble Antigen. Immunological Investigations, 38 (1). pp. 14-30.

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Abstract

To study the effects of immune cell activation by a protein antigen or lymphoid tissue derived cytokines on peripheral steroidogenesis activities of 3beta HSD and 17beta HSD was measured in lymphoid organs of control and BSA immunized mice after 3 weeks treatment. We demonstrated the presence of 3betaHSD and 17betaHSD in the lymphoid organs after active immunization. We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-alpha, IL-12p70, and IL-6, among which IL-12p70 and TNF-alpha down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	12 Feb 2020 05:14
Last Modified:	10 Dec 2021 09:11
URI:	http://nbrc.sciencecentral.in/id/eprint/610

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