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Mandal, PK and Tripathi, M and Akolkar, H (2012) Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel P-31 Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer's Disease. Journal of Alzheimer's disease.

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Abstract

Magnetic resonance spectroscopy (MRS) plays an important role in the understanding of membrane and energy metabolism. The outcome of MRS experiments helps to derive important cellular conditions (e.g., intracellular pH, energy, membrane metabolism, etc.), which are directly related to neuronal health. We present a novel multi-voxel 31P MRS imaging experimental scheme along with an advanced 31P signal processing technique to determine the pH and neurochemicals from both hippocampal areas in shorter time (13.2 min) for subjects (e.g. healthy young male/female, mild cognitive impairment (MCI) and Alzheimer's disease (AD)). Significant (p = 0.005) decrease of phosphomonoester (PME) and increase of phosphodiester (PDE) (p < 0.001), γ-ATP (0.008), and PCr (p = 0.001) levels in the left hippocampus of AD patients (n = 6) compared to the control subjects (n = 12) were found based on post-hoc ANOVA. On the other hand, in the right hippocampus, decrease in PME (p = 0.008) and increase in PDE (p < 0.001) were significant between AD patients and controls. In case of AD subjects, pH in the left hippocampus is increased towards alkaline side compared to MCI but did not reach statistical significance level. The pH (left hippocampus) in AD is found to be negatively correlated (r = -0.829, p = 0.042) with PCr level (left hippocampus) in AD subjects. In the left hippocampus, the increase in pH to alkaline range (in normal aging, pH is decreased to acidic range) along with statistically significant increments of PCr, γ-ATP, and PDE as well as decrease of PME in AD subjects provide extremely crucial clinical information, which can be used as biomarker for AD and potentially aid in the diagnosis. Mapping of Hippocampal pH and Neurochemicals from in vivo Multi-Voxel P-31 Study in Healthy Normal Young Male/Female, Mild Cognitive Impairment, and Alzheimer's Disease (PDF Download Available). Available from: https://www.researchgate.net/publication/221714461_Mapping_of_Hippocampal_pH_and_Neurochemicals_from_in_vivo_Multi-Voxel_P-31_Study_in_Healthy_Normal_Young_MaleFemale_Mild_Cognitive_Impairment_and_Alzheimer%27s_Disease [accessed May 4, 2017].

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 04 May 2017 10:46
Last Modified: 02 Jan 2018 09:31
URI: http://nbrc.sciencecentral.in/id/eprint/59

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