Das, Sulagna and Mishra, Manoj Kumar and Ghosh, Joydeep and Basu, Anirban (2008) Japanese Encephalitis Virus Infection Induce Il-18 and Il-1b in Microglia and Astrocytes: Correlation with in Vitro Cytokine Responsiveness of Glial Cells and Subsequent Neuronal Death. Journal of Neuroimmunology, 195. pp. 60-72.

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Abstract

IL-1beta and IL-18 are members of the IL-1 family of ligands, and their receptors are members of the IL-1 receptor family. Although several biological properties overlap for these cytokines, differences exist. In order to assess functional importance of these two cytokines in viral encephalitis, we have exploited an experimental model of Japanese Encephalitis (JE) and subsequent in vitro cell culture system. We report for the first time that in Japanese Encephalitis, microglia and astrocytes both produce IL-18 and IL-1beta. In vitro, these two cytokines differentially activate microglia and astrocyte, and also alter the by stander neuronal survival following treatment with these two cytokines.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	11 Feb 2020 05:26
Last Modified:	10 Dec 2021 09:38
URI:	http://nbrc.sciencecentral.in/id/eprint/585

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