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Joti, P and Kulashekhar, S and Behari, M and Murthy, A (2007) Impaired inhibitory oculomotor control in patients with Parkinson's disease. Exp Brain Res, 177 (4). pp. 447-457.

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A hallmark of voluntary control is the capacity to inhibit or change partially prepared responses, an ability thought to be compromised in patients with Parkinson's disease (PD). To test this hypothesis in relation to oculomotor control, PD patients and age-matched controls performed a redirect task in which they were instructed to cancel a partially prepared saccade on some random fraction of trials. Using a race model framework, the time it takes to cancel a saccade, the target switch reaction time (TSRT), was estimated for PD and control subjects. While saccadic reaction times of control and PD subjects were similar, the average TSRT in PD subjects was 139 ms, and was significantly greater than the TSRT in controls, which was 113 ms. These results support the hypothesis that poor voluntary control exhibited by PD patients in a variety of complex behaviors may be caused by impaired inhibitory control as a result of basal ganglia dysfunction.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 10 Feb 2020 10:03
Last Modified: 10 Feb 2020 10:03
URI: http://nbrc.sciencecentral.in/id/eprint/576

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