Kalmode, HP and Patil, SS and Handore, KL and Athawale, PR and Dandela, R and Verma, Abhishek Kumar and Basu, Anirban and Reddy, DS (2019) Neural Anti-Inflammatory Natural Product Periconianone A: Total Synthesis and Biological Evaluation. EURJOC, 2019 (13). pp. 2376-2381.

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Abstract

Total synthesis of periconianone A, an eremophilane‐type sesquiterpenoid with impressive neural anti‐inflammatory potential, has been accomplished. Diels–Alder/aldol strategy to construct tetrahydro‐naphthalene‐2,6‐dione scaffold, allylic oxidation of dienone using DBU/O2 and postulated biomimetic aldol reaction to construct 6/6/6 tricyclic system are the highlights of the present synthesis. Furthermore, the synthesized (±)‐periconianone A and two close analogs were tested for their neural anti‐inflammatory activity using various assays. In the course of our study we found a structurally simplified analog is superior to (±)‐periconianone A.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	06 Dec 2019 04:54
Last Modified:	09 Dec 2021 10:00
URI:	http://nbrc.sciencecentral.in/id/eprint/533

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