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Kumar, Ashutosh and Pareek, Vikas and Faiq, Muneeb A and Ghosh, Sanjib K and Kumari, Chiman (2019) ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications. Innov Clin Neurosci, 16 (5-6). pp. 30-37.


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Neurogenesis in adult humans remains a controversial area of research among neuroscientists. Methodological challenges have hampered investigators from conducting highquality, in-vivo studies that can help elucidate the presence and/or activity of neurogenesis in human brains. Additionally, the studies that have been done in humans report con� icting results, further adding to the ambiguity surrounding the concept of adult neurogenesis in humans. In this review article, the authors seek to help clarify the concept of adult neurogenesis by providing an overview of the basic concept, as we currently understand it, including its historical birth and evolution. The authors also review and discuss current key studies (pro and con) on adult neurogenesis in humans and animals, as well as research challenges with potential solutions. Finally, the authors discuss the clinical implications of adult neurogenesis in humans, based on what we know so far, including its potential use as a drug target in the development of pharmacological treatments for various neuropsychiatric disorders. KEYWORDS: Adult human neurogenesis, aging, hippocampus, olfactory bulb, neuropsychiatric disorders, neurorestoration

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 06 Sep 2019 05:46
Last Modified: 14 Dec 2021 05:14
URI: http://nbrc.sciencecentral.in/id/eprint/512

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