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Mahanti, S and Majhi, A and Kundu, K and Basu, A and Bishayi, B (2015) Systemic Staphylococcus aureus infection in restraint stressed mice modulates impaired immune response resulting in improved behavioral activities. Journal of Neuroimmunology, 288. pp. 102-113.

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Abstract

Stress leads to immune malfunction and increased susceptibility to infection resulting in impaired cognitive behavior and depression. Working with an animal model of Staphylococcus aureus infection and restraint stress we demonstrated impaired immune response and altered behavior against the S. aureus infection after exposure to acute or chronic restraint stress. This enhanced the resistance of mice to S. aureus infection via inhibiting the production of pro-inflammatory cytokines, free radicals, and upregulating corticosterone and antiinflammatory cytokine production, resulting in altered exploratory behavior, compared to non-stressed infected group (P b 0.05), thereby helping the animals to recover from depressive-like symptoms due to stress

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 17 Sep 2018 04:29
Last Modified: 17 Sep 2018 04:29
URI: http://nbrc.sciencecentral.in/id/eprint/464

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