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Handore, KL and Jadhav, PD and Hazra, B and Basu, A and Reddy, DS (2015) Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues. ACS Med Chem Lett, 6 (11). pp. 1117-1121.

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Abstract

The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 14 Sep 2018 09:54
Last Modified: 14 Sep 2018 09:54
URI: http://nbrc.sciencecentral.in/id/eprint/458

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