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Naik, Shruti and Banerjee, Arpan and Bapi, Raju S and Deco, Gustavo and Roy, Dipanjan (2017) Metastability in Senescence. Trends Cogn Sci, 21 (7). pp. 509-521.

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The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability. These structural changes are often accompanied by reorganization of functional brain networks. Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental. Despite numerous empirical investigations, the field lacks a coherent account of the dynamic processes that occur over our lifespan. Taking advantage of the recent developments in whole-brain computational modeling approaches, we hypothesize that the continuous process of aging can be explained by the concepts of metastability - a theoretical framework that gives a systematic account of the variability of the brain. This hypothesis can bridge the gap between existing theories and the empirical findings on age-related changes

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 02 Jan 2018 09:15
Last Modified: 13 Dec 2021 05:40
URI: http://nbrc.sciencecentral.in/id/eprint/303

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