Nazmi, Arshed and Dutta, Kallol and Das, Sulagna and Basu, Anirban (2011) Japanese Encephalitis Virus-Infected Macrophages Induce Neuronal Death. J Neuroimmune Pharmaco, 6 (3). pp. 420-433.

Text Japanese Encephalitis Virus Infected Macrophages Induces Neuronal Death J Neuroimmuno Pharmacology.pdf Restricted to Repository staff only Download (1056Kb) | Request a copy

Abstract

Inflammation in the central nervous system (CNS) in Japanese encephalitis (JE) is shown to be the result of microglial activation that leads to the release of various proinflammatory mediators. Peripheral macrophages have been reported to infiltrate into the CNS in JE, though their contribution to the inflammatory process is yet to be elucidated. In this study, using an in vitro macrophage model, we have shown that upon JE virus infection, these cells secrete various soluble factors which may significantly add to the existing inflammatory milieu and lead to apoptotic or necrotic death of neurons. However, it is difficult to quantify the extent of involvement of either the microglia or infiltrating macrophages in the inflammatory processes.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	02 Jan 2018 06:48
Last Modified:	10 Dec 2021 08:24
URI:	http://nbrc.sciencecentral.in/id/eprint/298

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