[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Tondon, S and Kambi, N and Lazar, L and Mohammed, H and Jain, N (2009) Large-Scale Expansion of the Face Representation in Somatosensory Areas of the Lateral Sulcus after Spinal Cord Injuries in Monkeys. J Neurosci, 29 (38). pp. 12009-12019.

[img] Text
09 S2-PV Reorganization JNeurosci Neeraj Jain.pdf
Restricted to Repository staff only

Download (1508Kb)

Abstract

Transection of dorsal columns of the spinal cord in adult monkeys results in large-scale expansion of the face inputs into the deafferented hand region in the primary somatosensory cortex (area 3b) and the ventroposterior nucleus of thalamus. Here, we determined whether the upstream cortical areas, secondary somatosensory (S2) and parietal ventral (PV) areas, also undergo reorganization after lesions of the dorsal columns. Areas S2, PV, and 3b were mapped after long-term unilateral lesions of the dorsal columns at cervical levels in adult macaque monkeys. In areas S2 and PV, we found neurons responding to touch on the face in regions in which responses to touch on the hand and other body parts are normally seen. In the reorganized parts of S2 and PV, inputs from the chin as well as other parts of the face were observed, whereas in area 3b only the chin inputs expand into the deafferented regions. The results show that deafferentations lead to a more widespread brain reorganization than previously known. The data also show that reorganization in areas S2 and PV shares a common substrate with area 3b, but there are specific features that emerge in S2 and PV.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 23 Oct 2017 05:17
Last Modified: 24 Oct 2017 11:31
URI: http://nbrc.sciencecentral.in/id/eprint/270

Actions (login required)

View Item View Item