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Shahi, MH and Zazpe, I and Afzal, M and Sinha, S and Rebhun, RB and Melendez, B and Rey, JA and Castresanaj, S (2015) Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumorsamples. Tumour Biol, 34 (4). pp. 2383-2391.

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Abstract

Glioma constitutes one of the most common groups of brain tumors, and its prognosis is influenced by different genetic and epigenetic modulations. In this study, we demonstrated low or no expression of hedgehog interacting protein (HHIP) in most of the cell lines and primary glioma tumor samples. We further proceeded to promoter methylation study of this gene in the same cell lines and primary tumor samples and found 87 % (7/8) HHIP methylation in glioblastoma cell lines and 75 % (33/44) in primary tumor samples. These methylation pattern correlates with low or unexpressed HHIP in both cell lines and primary tumor samples. Our results suggest the possibility of epigenetic regulation of this gene in glioma, similarly to medulloblastoma, gastric, hepatic, and pancreatic cancers. Also, HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Mr D.D. Lal
Date Deposited: 13 Jul 2017 07:13
Last Modified: 08 Aug 2017 04:46
URI: http://nbrc.sciencecentral.in/id/eprint/230

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