Palmal, S and Maity, AR and Singh, BK and Basu, S and Jana, NR (2014) Inhibition of amyloid fibril growth and dissolution of amyloid fibril by curcumin-gold nanoparticle. Chemistry-a European Journal, 20 (20). pp. 6184-6191.

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Abstract

Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.

Item Type:	Article
Subjects:	Neurodegenerative Disorders Neuro-Oncological Disorders Neurocognitive Processes Neuronal Development and Regeneration Informatics and Imaging Genetics and Molecular Biology
Depositing User:	Dr. D.D. Lal
Date Deposited:	10 Jul 2017 06:30
Last Modified:	11 Jan 2018 08:44
URI:	http://nbrc.sciencecentral.in/id/eprint/183

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