[feed] Atom [feed] RSS 1.0 [feed] RSS 2.0

Nazmi, A and Dutta, K and Hazra, B and Basu, A (2014) Role of pattern recognition receptors in flavivirus infections. Virus Res, 185. pp. 32-40.

[img] Text
144_Role of pattern recognition receptors in flavivirus infections.pdf
Restricted to Registered users only

Download (1419Kb)

Abstract

The flaviviral encephalitis has now become a major health concern in global scale. The efficient detection of viral infection and induction of the innate antiviral response by host's innate immune system are crucial to determine the outcome of infection. The intracellular pattern recognition receptors TLRs, RLRs, NLRs and CLRs play a central role in detection and initiation of robust antiviral response against flaviviral infection. Both cytoplasmic RLRs, RIG-I and MDA5 have been shown to be implicated in sensing flaviviral genomic RNA. Similarly among TLRs mainly TLR3 and TLR7 are known to respond in flaviviral infections as they are known to sense dsRNA and ssRNA moiety as their natural cognate ligand. Several studies have also shown the roles of NLRs and CLRs in mounting an innate antiviral response against flavivirus but, it is yet to be completely understood. Until now only few reports have implicated NLRs and CLRs in induction of antiviral and proinflammatory state following flaviviral infection. The current review therefore aims to comprehensively analyze past as well as current understanding on the role of PRRs in flaviviral infections.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Mr D.D. Lal
Date Deposited: 07 Jul 2017 05:59
Last Modified: 08 Aug 2017 05:20
URI: http://nbrc.sciencecentral.in/id/eprint/161

Actions (login required)

View Item View Item