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Bhutani, N and Sureshbabu, R and Faroogui, AA and Behari, M and Goyal, V and Murthy, A (2013) Queuing of concurrent movement plans by basal ganglia. J Neirpsci, 34 (24). pp. 9985-9997.

190_Queuing of concurrent movement plans by basal ganglia.pdf

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How the brain converts parallel representations of movement goals into sequential movements is not known. We tested the role of basal ganglia (BG) in the temporal control of movement sequences by a convergent approach involving inactivation of the BG by muscimol injections into the caudate nucleus of monkeys and assessing behavior of Parkinson's disease patients, performing a modified double-step saccade task. We tested a critical prediction of a class of competitive queuing models that explains serial behavior as the outcome of a selection of concurrently activated goals. In congruence with these models, we found that inactivation or impairment of the BG unmasked the parallel nature of goal representations such that a significantly greater extent of averaged saccades, curved saccades, and saccade sequence errors were observed. These results suggest that the BG perform a form of competitive queuing, holding the second movement plan in abeyance while the first movement is being executed, allowing the proper temporal control of movement sequences.

Item Type: Article
Subjects: Neurodegenerative Disorders
Neuro-Oncological Disorders
Neurocognitive Processes
Neuronal Development and Regeneration
Informatics and Imaging
Genetics and Molecular Biology
Depositing User: Dr. D.D. Lal
Date Deposited: 08 May 2017 08:39
Last Modified: 13 Mar 2020 09:33
URI: http://nbrc.sciencecentral.in/id/eprint/117

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